SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Opaleye Management Inc. (Last) (First) (Middle) 9B RUSSELL STREET (Street) CAMBRIDGE MA 02140 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 05/18/2015	3. Issuer Name and Ticker or Trading Symbol Imprimis Pharmaceuticals, Inc. [ IMMY ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Imprimis Pharmaceuticals, Inc.	1,167,199	I	See Footnote(1)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Securities reported herein for Opaleye Management, Inc. (the "Company) represent Common Stock beneficially owned and held of record by the Company and Opaleye, L.P., a private fund for which the Company serves as the investment manager (the "Fund"). James Silverman is the President and sole shareholder of the Company. The Company, the Fund and Mr. Silverman (the "Reporting Persons") are each beneficial owners and have an address of 9B Russell Street, Cambridge, MA 02140. The Reporting Persons disclaim beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares and warrants in which the Reporting Persons have no actual pecuniary interest therein.

	James Silverman, individually	05/20/2015
	James Silverman, as Manager of Opaleye GP LLC	05/20/2015
	James Silverman, as President of Opaleye Management, Inc.	05/20/2015
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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